Epstein F H, Mugler J P, Cail W S, Brookeman J R
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville, USA.
J Magn Reson Imaging. 1995 Jul-Aug;5(4):463-9. doi: 10.1002/jmri.1880050417.
Fluid-attenuated inversion recovery (FLAIR) is a pulse sequence used for acquiring T2-weighted images of the brain and spine in which the normally high signal intensity of CSF is greatly attenuated. The CSF-suppressed T2-weighted contrast of this technique may be more sensitive to a variety of disorders than that of conventional T2-weighted imaging. The primary disadvantage associated with conventional spin-echo implementations of FLAIR is the relatively limited anatomic coverage that can be achieved in a reasonable imaging time. We developed and optimized a three-dimensional magnetization-prepared rapid gradient-echo (3D MP-RAGE) pulse sequence that combines CSF-suppressed T2-weighted contrast similar to existing FLAIR techniques with anatomic coverage characteristic of 3D imaging. A preliminary evaluation of the new sequence was performed by imaging healthy volunteers and patients with multiple sclerosis.
液体衰减反转恢复（FLAIR）是一种用于获取大脑和脊柱T2加权图像的脉冲序列，在该序列中，脑脊液（CSF）通常的高信号强度会被大幅衰减。与传统T2加权成像相比，该技术的脑脊液抑制T2加权对比度可能对多种疾病更敏感。传统自旋回波实现的FLAIR的主要缺点是在合理的成像时间内可实现的解剖覆盖范围相对有限。我们开发并优化了一种三维磁化准备快速梯度回波（3D MP-RAGE）脉冲序列，该序列将类似于现有FLAIR技术的脑脊液抑制T2加权对比度与三维成像的解剖覆盖特性相结合。通过对健康志愿者和多发性硬化症患者进行成像，对新序列进行了初步评估。
