[乙型、丙型和丁型肝炎病毒在克卢日慢性肝病病因学中的作用]
[The role of the hepatitis B, C and D viruses in the etiology of chronic hepatopathies in Cluj].
作者信息
Neamţu A, Pascu O, Szanto P, Chira O, Neamţu D, State D
机构信息
Universitatea de Medicină şi Farmacie, Cluj-Napoca.
出版信息
Bacteriol Virusol Parazitol Epidemiol. 1995 Apr-Jun;40(2):119-23.
OBJECTIVE
We studied the prevalence of viral hepatitis B, C and D markers in chronic hepatopathies from Cluj.
MATERIAL AND METHODS
Sera of 297 patients with chronic hepatopathies (236 adults and 61 children) have been tested for viral hepatitis markers: HBsAg, anti-HBc, anti-HBs, HBeAg, anti-HBe, anti-HDV, anti-HCV, by automated ELISA.
RESULTS
HBV infection markers in 32% (adults) and 4.9% (children), and HDV infection markers in 11.8% (adults) and 26.3% (children). Double (HBV and HCV) and triple infection (HBV, HDV and HCV) were observed in 28.4% (adults), 4.9% (children), and 3.4% (adults), 0% (children), respectively.
CONCLUSIONS
Hepatitis virus infection markers, especially HBV and HCV play an important role in the determinism of chronic hepatopathies from Cluj area, both in children and adults.
目的
我们研究了克卢日慢性肝病患者中乙型、丙型和丁型病毒性肝炎标志物的流行情况。
材料与方法
采用自动酶联免疫吸附测定法，对297例慢性肝病患者（236例成人和61例儿童）的血清进行病毒性肝炎标志物检测：乙肝表面抗原（HBsAg）、乙肝核心抗体（抗-HBc）、乙肝表面抗体（抗-HBs）、乙肝e抗原（HBeAg）、乙肝e抗体（抗-HBe）、丁肝抗体（抗-HDV）、丙肝抗体（抗-HCV）。
结果
成人中乙肝病毒（HBV）感染标志物阳性率为32%，儿童为4.9%；成人中丁肝病毒（HDV）感染标志物阳性率为11.8%，儿童为26.3%。成人中HBV和HCV双重感染率为28.4%，儿童为4.9%；成人中HBV、HDV和HCV三重感染率为3.4%，儿童为0%。
结论
肝炎病毒感染标志物，尤其是HBV和HCV，在克卢日地区儿童和成人慢性肝病的发病机制中起着重要作用。
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