Mounier-Vehier C, Girard A, Consoli S, Laude D, Vacheron A, Elghozi J L
Centre de Pharmacologie Clinique, Association Claude Bernard, CNRS URA 1482, Faculty of Medicine Necker-E.M., Paris, France.
Clin Auton Res. 1995 Jun;5(3):145-50.
The response to the maze test was studied in 31 subjects on no medication, including seven subjects with mild essential hypertension. Beat-by-beat finger blood pressure (BP) was measured with a Finapres device. Pulse interval from which heart rate (HR) was derived was obtained from the BP signal. A period of 5 min baseline was used to define resting levels of systolic BP and HR using 20-s averaged values for the calculation of the 95% confidence limit of the two variables. The average test duration was 10 min. During this period a series of video-displayed mazes had to be solved with easy mazes preceding difficult ones. No subject had been exposed to the test before. The maximal BP elevation associated with the test was 27 mmHg. The HR response averaged 11 beats/min. Significant elevations were observed for half the test duration. No significant relationship between these two responses was observed and some subjects exhibited isolated systolic BP or HR responses. When indices obtained during this active mental stress were compared to resting values, positive correlations were observed. When the resting standard deviation (SD) of systolic BP was higher the systolic response was greater. A similar relationship was observed for HR. In addition, when the systolic BP level at rest was higher, the systolic BP reactivity index was greater. However, systolic BP or HR at baseline were not predictive of the systolic BP or HR responses. This study demonstrates the applicability of a new test to assess cardiovascular reactivity.(ABSTRACT TRUNCATED AT 250 WORDS)
对31名未服用药物的受试者进行了迷宫测试反应研究,其中包括7名轻度原发性高血压患者。使用Finapres设备逐搏测量手指血压(BP)。从BP信号中获取用于计算心率(HR)的脉搏间期。使用5分钟的基线期,通过20秒平均值来定义收缩压和心率的静息水平,以计算这两个变量的95%置信限。平均测试持续时间为10分钟。在此期间,一系列视频显示的迷宫需要解答,简单迷宫在前,困难迷宫在后。此前没有受试者接触过该测试。与测试相关的最大血压升高为27 mmHg。心率反应平均为11次/分钟。在测试持续时间的一半时间内观察到显著升高。未观察到这两种反应之间的显著关系,一些受试者表现出孤立的收缩压或心率反应。将这种主动精神应激期间获得的指标与静息值进行比较时,观察到正相关。当收缩压的静息标准差(SD)较高时,收缩反应更大。心率也观察到类似关系。此外,当静息时的收缩压水平较高时,收缩压反应性指数更大。然而,基线时的收缩压或心率并不能预测收缩压或心率反应。本研究证明了一种新测试在评估心血管反应性方面的适用性。(摘要截短至250字)