Takahashi H, Arakawa Y, Oki K, Sugita H, Sakamoto S, Kawabata Y
Fukujuji Hospital, Japan Anti-TB Association, Tokyo.
Int Arch Allergy Immunol. 1995;108 Suppl 1:2-5. doi: 10.1159/000237188.
Bronchoalveolar lavage was performed in patients with chronic eosinophilic pneumonia of unknown origin diagnosed histopathologically, and the alveolar fluid cells were investigated before and during corticosteroid therapy. The counts of eosinophils in bronchoalveolar lavage fluid decreased markedly during steroid therapy compared with before therapy, and the ratios of interleukin 2 receptor-positive T cells and HLA DR-positive T cells to all T lymphocytes in the lavage fluid also decreased. Both before and during steroid therapy, many macrophages in bronchoalveolar lavage fluid phagocytosed EG2-positive granules and stained immunohistochemically as CD71-positive 'responsive macrophages'. The decrease of activated T lymphocytes and the active phagocytosis of eosinophil granules by macrophages might play an important role in the mechanism of healing in chronic eosinophilic pneumonia.
对经组织病理学诊断为不明原因慢性嗜酸性粒细胞性肺炎的患者进行支气管肺泡灌洗，并在皮质类固醇治疗前和治疗期间对肺泡液细胞进行研究。与治疗前相比，类固醇治疗期间支气管肺泡灌洗液中的嗜酸性粒细胞计数显著下降，灌洗液中白细胞介素2受体阳性T细胞和HLA DR阳性T细胞与所有T淋巴细胞的比例也下降。在类固醇治疗前和治疗期间，支气管肺泡灌洗液中的许多巨噬细胞吞噬EG2阳性颗粒，并在免疫组织化学上染色为CD71阳性的“反应性巨噬细胞”。活化T淋巴细胞的减少以及巨噬细胞对嗜酸性粒细胞颗粒的活跃吞噬可能在慢性嗜酸性粒细胞性肺炎的愈合机制中起重要作用。
