Shinohara Tsutomu, Tsuji Shoutaro, Okano Yoshio, Machida Hisanori, Hatakeyama Nobuo, Ogushi Fumitaka
Department of Clinical Investigation, National Hospital Organization Kochi Hospital, Japan.
Molecular Diagnostic Project, Kanagawa Cancer Center Research Institute, Japan.
Intern Med. 2018 Dec 15;57(24):3507-3514. doi: 10.2169/internalmedicine.0841-18. Epub 2018 Aug 10.
Objective Human intelectin-1 (hITLN-1) binds to galactofuranosyl residues, which are present in the microbial cell wall, but which are absent in mammalian tissues, and has been suggested to play an immunological role against microorganisms. However, the involvement of hITLN-1 in the pathogenesis of diffuse pulmonary diseases remains unknown. The aim of this study was to compare the hITLN-1 concentrations in the bronchoalveolar lavage (BAL) fluid of patients with diffuse pulmonary diseases. Methods The cell components and concentrations of hITLN-1 were analyzed in the BAL fluid of 8 patients with idiopathic chronic eosinophilic pneumonia (ICEP), 3 patients with drug-induced eosinophilic pneumonia, 4 patients with hypersensitivity pneumonitis (HP), 11 patients with sarcoidosis, 9 patients with cryptogenic organizing pneumonia, and 5 patients with idiopathic fibrosing interstitial pneumonia (fibrosing nonspecific interstitial pneumonia or usual interstitial pneumonia). Results The hITLN-1 concentrations in the BAL fluid of patients with ICEP and HP were higher than in those with other diseases. In the ICEP group, no significant difference was observed in the hITLN-1 concentrations of patients with or without a history of bronchial asthma. Conclusion The results of the present study suggest that hITLN-1 may be involved in the pathogenesis of ICEP and HP, and that an increase in the hITLN-1 concentration in the BAL fluid may represent a new biomarker for these diseases.
目的 人凝集素-1（hITLN-1）可与存在于微生物细胞壁中但在哺乳动物组织中不存在的呋喃半乳糖基残基结合，并且有人提出其在针对微生物的免疫反应中发挥作用。然而，hITLN-1在弥漫性肺部疾病发病机制中的作用尚不清楚。本研究的目的是比较弥漫性肺部疾病患者支气管肺泡灌洗（BAL）液中hITLN-1的浓度。方法 分析了8例特发性慢性嗜酸性粒细胞性肺炎（ICEP）患者、3例药物性嗜酸性粒细胞性肺炎患者、4例过敏性肺炎（HP）患者、11例结节病患者、9例隐源性机化性肺炎患者和5例特发性纤维性间质性肺炎（纤维性非特异性间质性肺炎或普通间质性肺炎）患者BAL液中的细胞成分和hITLN-1浓度。结果 ICEP和HP患者BAL液中的hITLN-1浓度高于其他疾病患者。在ICEP组中，有或无支气管哮喘病史的患者hITLN-1浓度无显著差异。结论 本研究结果表明，hITLN-1可能参与ICEP和HP的发病机制，BAL液中hITLN-1浓度的升高可能是这些疾病的一种新生物标志物。
