Kakazu T, Chihara J, Saito A, Nakajima S
Fourth Department of Internal Medicine, Kinki University, Osaka, Japan.
Int Arch Allergy Immunol. 1995;108 Suppl 1:9-11. doi: 10.1159/000237190.
RANTES, a member of the 8-kDa cytokine family, has been shown to possess chemotactic activity for eosinophils. In this study, RANTES augmented isolated human eosinophil adhesion to plates coated with recombinant soluble intercellular adhesion molecule 1. In addition, RANTES did not augment the expression of beta 2-integrin adhesion molecules (lymphocyte function associated antigen-1 alpha (LFA-1 alpha), LFA-1 beta, complement receptor type 3 (CR3)) on human eosinophils. These findings suggest that RANTES not only modulates the chemotactic activity of eosinophils but also intensifies the function of eosinophil adhesion without augmenting the expression of beta 2-integrin adhesion molecules.
RANTES是8 kDa细胞因子家族的成员之一，已被证明对嗜酸性粒细胞具有趋化活性。在本研究中，RANTES增强了分离的人嗜酸性粒细胞与包被有重组可溶性细胞间黏附分子1的平板的黏附。此外，RANTES并未增强人嗜酸性粒细胞上β2整合素黏附分子（淋巴细胞功能相关抗原-1α（LFA-1α）、LFA-1β、3型补体受体（CR3））的表达。这些发现表明，RANTES不仅调节嗜酸性粒细胞的趋化活性，还增强嗜酸性粒细胞的黏附功能，而不增加β2整合素黏附分子的表达。
