Hayashi N, Chihara J, Kobayashi Y, Kakazu T, Kurachi D, Yamamoto T, Nakajima S
Fourth Department of Internal Medicine, Kinki University, Japan.
Int Arch Allergy Immunol. 1994;104 Suppl 1(1):57-9. doi: 10.1159/000236754.
The effect of platelet-activating factor (PAF) and platelet factor 4 (PF4) on the adhesion of isolated human eosinophils or eosinophilic cell lines (EoL-1, EoL-3) was examined. Both PAF and PF4 augmented eosinophil adhesion to plates coated with AB plasma or recombinant soluble intercellular adhesion molecule-1 (r-sICAM-1). These findings suggest that PAF and PF4 not only modulate chemotactic activity of eosinophils but also intensify the function of eosinophil adhesion. Since PAF and PF4 induce the expression of adhesion molecules (LFA-1 alpha, LFA-1 beta, CR3) on eosinophils, we could conclude that PAF or PF4 are closely related to eosinophil accumulation not only as chemotactic agents but also as augmentative agents for eosinophil adhesion through involvement in functional eosinophil adherence as well as surface expression of adhesion molecules on eosinophils.
研究了血小板活化因子（PAF）和血小板因子4（PF4）对分离的人嗜酸性粒细胞或嗜酸性细胞系（EoL-1、EoL-3）黏附的影响。PAF和PF4均增强了嗜酸性粒细胞对包被有AB血浆或重组可溶性细胞间黏附分子-1（r-sICAM-1）的平板的黏附。这些发现表明，PAF和PF4不仅调节嗜酸性粒细胞的趋化活性，还增强嗜酸性粒细胞的黏附功能。由于PAF和PF4诱导嗜酸性粒细胞上黏附分子（LFA-1α、LFA-1β、CR3）的表达，我们可以得出结论，PAF或PF4不仅作为趋化剂，而且作为嗜酸性粒细胞黏附的增强剂，通过参与嗜酸性粒细胞的功能性黏附以及嗜酸性粒细胞上黏附分子的表面表达，与嗜酸性粒细胞的积聚密切相关。
