Orlandi M, Raimondi W, Oddone A, Berra R, Tommasini G, Birolli M, Malusardi R
G Ital Cardiol. 1978;8 Suppl 1:223-7.
Of 335 consecutive patients (pts) admitted to the coronary care unit (CCU) for acute myocardial infarction (AMI), 34 (10%) evidenced complete heart block (HB). The overall inhospital mortality was 14% (47 pts) versus 39% of the HB group (13 pts). No previous conduction disturbances were documented in 58% of pts before appearance of complete HB. Complete HB was preceded in 52% of pts by first or second degree HB or bundle branch block. Of 21 pts with HB discharged from the hospital, 5 (23%) died between 5 and 24 months (mean 12): no patients had sudden death; 16 pts (76%) are still alive after 13 to 45 months (mean 30). His bundle electrophysiologic (HBE) study was performed in 10 pts of the HB group after 4 to 40 months: 4 pts with anterior versus 6 with inferior AMI. Conduction disturbances were no longer present in all but one pt who had H-V 60 msec. Ajmaline (50 + 50 mg iv) prolonged A-H over 130 msec in 4 pts; H-V was not significantly increased in 8 of the 10 pts, while in two pts was 100 msec. One pt in the acute phase and one pt 12 months later, required pacemaker (PM) implant (both had inferior MI).
no sudden death was documented during the follow-up period. The late HBE study, before and after ajmaline, did not allow to recognize critical conduction abnormalities suggessting prophylactic PM implantation.
在335例因急性心肌梗死(AMI)入住冠心病监护病房(CCU)的连续患者中,34例(10%)出现完全性心脏传导阻滞(HB)。总体住院死亡率为14%(47例患者),而HB组为39%(13例患者)。58%的患者在出现完全性HB之前未记录到先前的传导障碍。52%的患者在完全性HB之前出现一度或二度HB或束支传导阻滞。在21例出院的HB患者中,5例(23%)在5至24个月(平均12个月)之间死亡;无患者猝死;16例(76%)在13至45个月(平均30个月)后仍存活。在HB组的10例患者中,在4至40个月后进行了希氏束电生理(HBE)研究:4例前壁AMI患者与6例下壁AMI患者。除1例H-V为60毫秒的患者外,所有患者的传导障碍均不再存在。阿义马林(50 + 50毫克静脉注射)使4例患者的A-H延长超过130毫秒;10例患者中的8例H-V未显著增加,而2例患者为100毫秒。1例急性期患者和1例12个月后的患者需要植入起搏器(PM)(均为下壁心肌梗死)。
随访期间未记录到猝死。阿义马林前后的晚期HBE研究未能识别提示预防性植入PM的关键传导异常。