Fleming T G
Biochemistry Laboratory, Altnagelvin Area Hospital, Londonderry, Northern Ireland, UK.
Br J Biomed Sci. 1995 Mar;52(1):50-7.
von Willebrand factor (vWF) is a complex protein essential to normal haemostasis. It is vital to platelet adhesion in the high shear stress conditions encountered in the small blood vessels. Deficient overall levels of, or the presence of abnormally functioning variants of, vWF lead to the common bleeding disorder termed von Willebrand's disease. Laboratory investigation is aimed at both quantitative and qualitative investigation with a view to classification of the abnormality for each individual patient into a particular sub-type.
血管性血友病因子（vWF）是一种对正常止血至关重要的复合蛋白。在小血管中遇到的高剪切应力条件下，它对血小板黏附至关重要。vWF的总体水平不足或存在功能异常的变体，会导致一种常见的出血性疾病，称为血管性血友病。实验室检查旨在进行定量和定性研究，以便将每个患者的异常情况分类为特定的亚型。
