Kincade P W
Oklahoma Medical Research Foundation, Oklahoma City 73104.
Semin Immunol. 1991 Nov;3(6):379-90.
Long term culture techniques, cloned stromal lines, recombinant cytokines and monoclonal antibodies have provided powerful experimental tools for studying bone marrow functions. Rapid progress has been made in characterizing large reticular stromal cells in bone marrow that provide a nurturing microenvironment for B lymphocyte precursors. It is now clear that they have differentiation potential, that they can respond to inflammatory episodes and that they can make at least 12 regulatory cytokines. Pairs of cell adhesion molecules have also been defined which participate in B lymphopoiesis. These include CD44, hyaluronate, VLA-4 and a VCAM-like protein.
长期培养技术、克隆基质系、重组细胞因子和单克隆抗体为研究骨髓功能提供了强大的实验工具。在鉴定骨髓中为B淋巴细胞前体提供滋养微环境的大型网状基质细胞方面已取得快速进展。现在很清楚，它们具有分化潜能，能够对炎症发作作出反应，并且能够产生至少12种调节性细胞因子。还确定了参与B淋巴细胞生成的成对细胞粘附分子。这些包括CD44、透明质酸、VLA-4和一种类VCAM蛋白。
