Lipton M J, Higgins C B, Wiley A A, Angell W W, Barry W H
Invest Radiol. 1978 Nov-Dec;13(6):519-22. doi: 10.1097/00004424-197811000-00007.
The intravascular injection of contrast medium produces a rise of ventricular filling pressure which may reflect blood volume expansion, a negative inotropic effect on the myocardium, and/or a decrease in ventricular diastolic compliance. This phenomenon was studied by randomly infusing three substances, Renografin-76, 1% saline and 38% sucrose, into the aortic root of the isolated perfused canine heart. The preparation was modified by having an inflated ballon within the left ventricular cavity so that the end diastolic ventricular volume and afterload were fixed. A dose-related depression of left ventricular systolic pressure and peak dP/dt due to contrast media occurred, without a significant change in the left ventricular diastolic pressure. This decrease in ventricular contractility due to Renografin-76 could not be attributed entirely to either a saline or an osmotic effect. No significant changes were observed in left ventricular diastolic compliance. Sucrose was found to exhibit a marked positive inotropic effect.
血管内注射造影剂会使心室充盈压升高，这可能反映血容量增加、对心肌的负性肌力作用和/或心室舒张顺应性降低。通过将三种物质（泛影葡胺-76、1%盐水和38%蔗糖）随机注入离体灌注犬心的主动脉根部来研究这一现象。通过在左心室内放置一个充气气球来改变实验装置，以使舒张末期心室容积和后负荷固定。造影剂导致左心室收缩压和峰值dP/dt呈剂量相关下降，而左心室舒张压无显著变化。泛影葡胺-76导致的心室收缩力下降不能完全归因于盐水或渗透作用。左心室舒张顺应性未观察到显著变化。发现蔗糖具有明显的正性肌力作用。
