Nelson J A
Invest Radiol. 1978 Nov-Dec;13(6):541-3. doi: 10.1097/00004424-197811000-00011.
Iopanoate saturation kinetics were measured in four dogs both drug free and following six days of low dose aspirin ingestion. Each animal acted as its own control. In post aspirin ingestion studies there was s significant (P less than .001) decrease in the apparent Vmax of iopanoate. The volume of distribution showed no significant change, and gallbladder visualization showed no significant change despite the decrease in Vmax. Although aspirin pretreatment decreases the control Vmax by 50%, its mechanism and significance in the clinical setting will require further study.
在四只狗身上测量了碘番酸的饱和动力学，分别在无药物状态下以及在摄入低剂量阿司匹林六天后进行测量。每只动物自身作为对照。在摄入阿司匹林后的研究中，碘番酸的表观最大反应速率（Vmax）显著降低（P小于0.001）。分布容积无显著变化，尽管Vmax降低，但胆囊显影无显著变化。虽然阿司匹林预处理使对照Vmax降低了50%，但其在临床环境中的机制和意义仍需进一步研究。
