Koehler R E, Goldberg H I
Invest Radiol. 1977 May-Jun;12(3):267-72. doi: 10.1097/00004424-197705000-00011.
Cholangiography and cholecystography were performed in fasted dogs and human subjects using sodium iopanoate given intraduodenally in doses of 10 and 20 mg/kg. The same studies were performed after intraduodenal administration of fat or after intravenous administration of cholecystokinin (CCK) in dogs and after a fatty meal, to stimulate endogenous release of CCK, in human subjects. In both the animals and human subjects, peak blood iodine concentrations were reached by 30 minutes after iopanoate administration. At a dose of 10 mg/kg, radiographic visualization of both bile ducts and gallbladder was inconsistent. At 20 mg/kg (one-half the clinical dose for standard oral cholecystography,) the common bile duct was visualized within 60 minutes and the gallbladder within 90 minutes. Gallbladder density increased over the next 6 hours. Prior administration of fat or CCK led to earlier and denser gallbladder opacification. The common bile ducts opacified with the use of iopanoate were small in caliber, averaging only 3 mm. This probably reflects the fact that, unlike iodipamide, iopanoate has little or no choleretic effect. Therefore, because it would not increase the volume of bile in the duct, iopanoate would not increase duct size.
在禁食的犬类和人类受试者中进行胆管造影和胆囊造影，十二指肠内给予碘番酸钠，剂量为10和20mg/kg。在犬类中，十二指肠内给予脂肪或静脉注射胆囊收缩素（CCK）后进行同样的研究；在人类受试者中，给予高脂餐以刺激内源性CCK释放后进行同样的研究。在动物和人类受试者中，碘番酸钠给药后30分钟达到血碘浓度峰值。剂量为10mg/kg时，胆管和胆囊的放射显影不一致。在20mg/kg（标准口服胆囊造影临床剂量的一半）时，60分钟内可见胆总管显影，90分钟内可见胆囊显影。在接下来的6小时内胆囊密度增加。预先给予脂肪或CCK可使胆囊更早且更浓密地显影。使用碘番酸钠显影的胆总管管径较小，平均仅3mm。这可能反映了这样一个事实，即与碘达胺不同，碘番酸钠几乎没有利胆作用。因此，由于它不会增加胆管内胆汁的量，碘番酸钠不会使胆管管径增大。
