Herzog R J, Nelson J A
Invest Radiol. 1976;11(5):440-7. doi: 10.1097/00004424-197609000-00149.
Studies of the effect of cholecystokinin (CCK) on hepatic elimination of intravenously administered iopanoate and on gallbladder opacification were performed using nonoperated dogs with intact enterohepatic circulation and normal endogenous bile salt pool. Intravenous administration of CCK (3 units/kg) resulted in a 32% increase in apparent transport maximum (maximum rate of elimination) of iopanoate and earlier and enhanced gallbladder opacification. This increase in apparent transport maximum was abolished by cholecystectomy, indicating that the increase was a result of the release of bile salts from the gallbladder rather than a direct effect of the hormone on the hepatic elimination of iopanoate. The early gallbladder opacification and increased density of contrast material in the gallbladder were related to CCK-induced emptying of the gallbladder and subsequent filling with opacified bile.
利用具有完整肠肝循环和正常内源性胆盐池的未手术犬，开展了关于胆囊收缩素（CCK）对静脉注射碘番酸肝脏清除率及胆囊显影影响的研究。静脉注射CCK（3单位/千克）使碘番酸的表观转运最大值（最大清除率）提高了32%，并使胆囊显影更早且增强。胆囊切除术后，这种表观转运最大值的增加被消除，这表明该增加是胆囊释放胆盐的结果，而非该激素对碘番酸肝脏清除的直接作用。胆囊早期显影及胆囊内造影剂密度增加与CCK诱导的胆囊排空及随后充满显影胆汁有关。
