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[地西泮对具有不同正常情绪性的大鼠大脑切片及处于情绪应激状态下的大鼠大脑切片中羧肽酶N和血管紧张素转换酶活性的影响]

[The effect of diazepam on the activity of carboxypeptidase N and the angiotensin-converting enzyme in sections of the brain of rats with differing normal emotionality and in emotional stress].

作者信息

Nikishin N N, Vernigora A N, Gengin M T

出版信息

Fiziol Zh Im I M Sechenova. 1994 Dec;80(12):108-13.

PMID:7550425
Abstract

Diazepam increased the carboxypeptidase H activity and decreased the angiotensin converting enzyme activity in the rat brain. Joint action of diazepam and emotional stress changed the carboxypeptidase H activity to the least extent and the angiotensin converting enzyme activity to the utmost extent as compared to the agents' separate effects. The role of both enzymes in the diazepam effect is discussed.

摘要

地西泮可增加大鼠脑内羧肽酶H的活性，并降低血管紧张素转换酶的活性。与单独使用药物相比，地西泮与情绪应激的联合作用对羧肽酶H活性的改变最小，而对血管紧张素转换酶活性的改变最大。本文讨论了这两种酶在地西泮作用中的作用。

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