Nikishin N N, Vernigora A N, Gengin M T
Fiziol Zh Im I M Sechenova. 1994 Dec;80(12):108-13.
Diazepam increased the carboxypeptidase H activity and decreased the angiotensin converting enzyme activity in the rat brain. Joint action of diazepam and emotional stress changed the carboxypeptidase H activity to the least extent and the angiotensin converting enzyme activity to the utmost extent as compared to the agents' separate effects. The role of both enzymes in the diazepam effect is discussed.
地西泮可增加大鼠脑内羧肽酶H的活性,并降低血管紧张素转换酶的活性。与单独使用药物相比,地西泮与情绪应激的联合作用对羧肽酶H活性的改变最小,而对血管紧张素转换酶活性的改变最大。本文讨论了这两种酶在地西泮作用中的作用。