Shapovalova K B, Zhuravin I A, Pominova E V, Dubrovskaia N M, Diubkacheva G A
Fiziol Zh Im I M Sechenova. 1994 Dec;80(12):34-44.
The role of the neostriatal cholinergic system in the regulation of sensory controlled movements were studied using two behavioral models: 1) maintenance acquired extension of forelimb during proper time (rats) and 2) prolonged conditional flexion of hindlimb (dogs). It was found that injections of carbacholine (Car, 0.03 mkg) into the dorsolateral part of nucleus caudatus (NCd) of rats did not considerable change the movement connected with maintenance of forelimb tonus, while injections of Car (0.05-0.1 mkg) into the same area of the NCd of dogs were accompanied by improved performance of movement connected with maintenance of hindlimb tonus. It is possible to suggest the follows: 1. The neostriatal mechanisms of regulation of fore- and hindlimb tonus maintenance are different. 2. The neostriatal mediator of mechanisms of tonus regulation and regulation of somesthetic control of maintenance of this tonus are probably different too. Bilateral Car microinjections (0.03 mkg) into NCd of rats improved the discriminative active avoidance learning in T-maze. The discrimination of sound signals in dogs were also significantly improved after Car injections (0.05-0.1 mkg) into the NCd. Thus, data obtained at the different behavioral models and different animals suggest that cholinergic system of Neostriatum takes part in the regulation of both motor and sensory components of learned movements realization. The possible mechanisms of this regulation are discussed.
1）在适当时间维持获得性前肢伸展（大鼠）和2）后肢长时间条件性屈曲（犬）。结果发现，向大鼠尾状核背外侧部分注射卡巴胆碱（Car，0.03微克）对与维持前肢紧张度相关的运动没有显著影响，而向犬尾状核同一区域注射Car（0.05 - 0.1微克）则伴随着与维持后肢紧张度相关的运动表现改善。可以提出以下几点：1. 新纹状体调节前肢和后肢紧张度维持的机制不同。2. 调节紧张度的新纹状体介质以及调节这种紧张度维持的躯体感觉控制的介质可能也不同。向大鼠尾状核双侧微量注射Car（0.03微克）可改善T迷宫中的辨别性主动回避学习。向犬尾状核注射Car（0.05 - 0.1微克）后，犬对声音信号的辨别能力也显著提高。因此，在不同行为模型和不同动物上获得的数据表明，新纹状体胆碱能系统参与了学习运动实现的运动和感觉成分的调节。讨论了这种调节的可能机制。
