Dubrovskaya N M, Zhuravin I A
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Neurosci Behav Physiol. 1998 Jul-Aug;28(4):386-91. doi: 10.1007/BF02464792.
Comparative studies were performed of the effects of injections of a cholinergic agonist (carbachol) and antagonist (scopolamine) into the ventral and dorsal striatum on the performance of a learned movement involving prolonged maintenance of extension of the forelimb in rats. Doses of carbachol (0.03-3.00 micrograms) into the ventral striatum were accompanied by increases in the numbers of movements with prolonged maintenance of extension with application of pressure against an obstacle, with a simultaneous decrease in the percentage of rapid nonreinforced movements (by an average of 18.8%). Injections into the dorsal striatum disrupted slow movements which were not reinforced during training, on a background of stable performance of the learned reflex. Doses of scopolamine (0.3-3.0 micrograms) into both the dorsal and ventral parts of the striatum produced increases (by 22.7 +/- 8.2% and 68.9 +/- 14.3%) in the numbers of rapid nonreinforced movements typical of the repertoire of untrained animals. These data led to the suggestion that the cholinergic system of the ventral striatum is involved in the maintenance of forelimb muscle tone in rats during the performance of movements in which pressure is applied to an obstacle. The cholinergic system of the dorsal striatum does not have this property, but plays a significant role in the process of learning new sensory-controlled movements.
对大鼠腹侧和背侧纹状体注射胆碱能激动剂（卡巴胆碱）和拮抗剂（东莨菪碱），比较其对涉及前肢长时间伸展的习得性运动表现的影响。向腹侧纹状体注射剂量为0.03 - 3.00微克的卡巴胆碱，会使在对障碍物施加压力时前肢长时间伸展的运动次数增加，同时快速非强化运动的百分比下降（平均下降18.8%）。在习得性反射表现稳定的背景下，向背侧纹状体注射会破坏训练期间未强化的缓慢运动。向纹状体背侧和腹侧注射剂量为0.3 - 3.0微克的东莨菪碱，会使未训练动物行为中典型的快速非强化运动次数增加（分别增加22.7 +/- 8.2%和68.9 +/- 14.3%）。这些数据表明，腹侧纹状体的胆碱能系统在大鼠对障碍物施加压力的运动过程中参与维持前肢肌肉张力。背侧纹状体的胆碱能系统不具备此特性，但在学习新的感觉控制运动过程中发挥重要作用。
