Shapovalova K B, Pominova E V, Diubkacheva T A
Fiziol Zh Im I M Sechenova. 1996 Feb;82(2):1-12.
The learning of discriminative avoidance reflex in T-maze was studied on 57 Sprague-Dawley rats (divided into several experimental groups) at the normal conditions, both after carbacholine (0.03 mkg), or scopolamine (0.3 mkg) microinjections into neostriatum bilaterally, after uni- or bilateral lesions of intralaminar thalamic nucleus (Pf) and after neostriatal microinjections followed Pf lesion. It has been shown that bilateral carbacholine microinjections in neostriatum (in 4, 5 and 6 days of learning) significantly increased (p < 0.01) the level of correct realizations of discriminative avoidance reflex. Bilateral lesion of Pf resulted in irreversible destruction of preliminary learned active avoidance movement. In rats with preliminary lesion of Pf nuclei we had no possibility of learn discriminative avoidance reflex during 10 experimental days (160 trials). The neostriatal carbacholine microinjections to these animals didn't show any effect. It was concluded that intact afferent input from Pf nucleus is significant for activation of neostriatal neuronal background, necessary for cholinergic activation effect.
在正常条件下，对57只斯普拉格-道利大鼠（分为几个实验组）进行了T迷宫中辨别性回避反射学习的研究，实验分别在双侧新纹状体内微量注射卡巴胆碱（0.03微克）或东莨菪碱（0.3微克）后、丘脑板内核（Pf）单侧或双侧损伤后以及Pf损伤后新纹状体微量注射后进行。结果表明，双侧新纹状体内微量注射卡巴胆碱（在学习的第4、5和6天）显著提高（p<0.01）了辨别性回避反射的正确完成水平。Pf双侧损伤导致先前习得的主动回避运动不可逆转地被破坏。在Pf核预先损伤的大鼠中，在10个实验日（160次试验）内无法学习辨别性回避反射。对这些动物进行新纹状体卡巴胆碱微量注射未显示任何效果。得出的结论是，来自Pf核的完整传入输入对于激活新纹状体神经元背景很重要，而这是胆碱能激活效应所必需的。
