Tikhonravov D L, Shapovalova K B, Diubkacheva T A
I.P. Pavlov Institute of Physiology Russian Acad. Sci., St. Petersburg.
Fiziol Zh Im I M Sechenova. 1995 Aug;81(8):139-46.
In chronic experiments in 32 male Sprague-Dawley rats on the model of food instrumental reflex (Skinner box) it was shown that the effect of Neostriatal scopolamine microinjections (0.3 mkg) depended on the stage of reflex consolidation. Before the complete reflex consolidation the bilateral microinjections of scopolamine into Nucleus Caudatus produce prolonged inhibition of instrumental reflex. Bilateral Neostriatal microinjections of scopolamine in the same doze had no effect in the case of full consolidation of instrumental reflex. Our results suggest that the cholinergic Neostriatal system is crucially involved in the forming of motor engram of instrumental reaction. In the same time the cholinergic neostriatal system either is not involved in the execution of full consolidate instrumental reactions, or another different forebrain structures patricipate in their realization compensating disturbances of striatal cholinergic function.
在32只雄性斯普拉格-道利大鼠上进行的关于食物操作性反射模型（斯金纳箱）的慢性实验表明，新纹状体注射东莨菪碱（0.3微克）的效果取决于反射巩固阶段。在反射完全巩固之前，向尾状核双侧微量注射东莨菪碱会导致操作性反射的长时间抑制。在操作性反射完全巩固的情况下，以相同剂量双侧新纹状体注射东莨菪碱则没有效果。我们的结果表明，胆碱能新纹状体系统在操作性反应运动记忆痕迹的形成中起关键作用。同时，胆碱能新纹状体系统要么不参与完全巩固的操作性反应的执行，要么有其他不同的前脑结构参与其实现，以补偿纹状体胆碱能功能的紊乱。
