Determination of chloramphenicol in animal tissue using high-performance liquid chromatography with a column-switching system and ultraviolet detection.

A rapid and universally applicable method for determination of chloramphenicol (CAP) residues in animal tissues using high-performance liquid chromatography with a column-switching system is presented. The clean-up procedure as well as the chromatographic conditions and detection are described. The linearity and repeatability of the data obtained by this method as well as the recovery rates of CAP in several farm animals are presented.