Collins M
CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, United Kingdom.
Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 2):S20-4. doi: 10.1164/ajrccm/152.4_Pt_2.S20.
Apoptosis is a physiologic mechanism of cell death that is induced during development or reversible tissue expansion or after tissue damage to eliminate unwanted cells. Recently, viral gene products have been shown to either specifically induce or specifically inhibit apoptosis. In this review, our current understanding of the regulation of apoptosis is outlined. The mechanisms by which viruses can inhibit or induce apoptosis are described. The role of apoptosis in modulating the immune response to viral infection is discussed. Finally, the hypothesis is advanced that the balance between induction and inhibition of apoptosis is modulated by viruses to optimize the course of viral infection.
细胞凋亡是一种细胞死亡的生理机制，在发育过程中、可逆性组织扩张期间或组织损伤后被诱导，以消除不需要的细胞。最近，已表明病毒基因产物可特异性诱导或特异性抑制细胞凋亡。在这篇综述中，概述了我们目前对细胞凋亡调控的理解。描述了病毒抑制或诱导细胞凋亡的机制。讨论了细胞凋亡在调节对病毒感染的免疫反应中的作用。最后，提出了一种假说，即病毒调节细胞凋亡诱导与抑制之间的平衡，以优化病毒感染的进程。
