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细胞凋亡在猪对病毒感染的反应及猪肠道致病性冠状病毒发病机制中的作用

The Roles of Apoptosis in Swine Response to Viral Infection and Pathogenesis of Swine Enteropathogenic Coronaviruses.

作者信息

Xu Zhichao, Zhang Yun, Cao Yongchang

机构信息

State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou, China.

Higher Education Mega Center, School of Life Science, Sun Yat-sen University, Guangzhou, China.

出版信息

Front Vet Sci. 2020 Nov 26;7:572425. doi: 10.3389/fvets.2020.572425. eCollection 2020.

DOI:10.3389/fvets.2020.572425
PMID:33324698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7725767/
Abstract

Apoptosis is a tightly regulated mechanism of cell death that plays important roles in various biological processes including biological evolution, multiple system development, anticancer, and viral infections. Swine enteropathogenic coronaviruses invade and damage villous epithelial cells of the small intestine causing severe diarrhea with high mortality rate in suckling piglets. (TGEV), (PEDV), (PDCoV), and (SADS-CoV) are on the top list of commonly-seen swine coronaviruses with a feature of diarrhea, resulting in significant economic losses to the swine industry worldwide. Apoptosis has been shown to be involved in the pathogenesis process of animal virus infectious diseases. Understanding the roles of apoptosis in host responses against swine enteropathogenic coronaviruses infection contribute to disease prevention and control. Here we summarize the recent findings that focus on the apoptosis during swine coronaviruses infection, in particular, TGEV, PEDV, PDCoV, and SADS-CoV.

摘要

细胞凋亡是一种严格调控的细胞死亡机制，在包括生物进化、多系统发育、抗癌和病毒感染在内的各种生物学过程中发挥着重要作用。猪肠道致病性冠状病毒侵袭并损伤小肠绒毛上皮细胞，导致哺乳仔猪严重腹泻，死亡率很高。（传染性胃肠炎病毒）、（猪流行性腹泻病毒）、（猪德尔塔冠状病毒）和（猪急性腹泻综合征冠状病毒）是常见的具有腹泻特征的猪冠状病毒，给全球养猪业造成了重大经济损失。细胞凋亡已被证明参与动物病毒感染性疾病的发病过程。了解细胞凋亡在宿主对抗猪肠道致病性冠状病毒感染反应中的作用有助于疾病的预防和控制。在此，我们总结了最近关于猪冠状病毒感染过程中细胞凋亡的研究发现，特别是传染性胃肠炎病毒、猪流行性腹泻病毒、猪德尔塔冠状病毒和猪急性腹泻综合征冠状病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/bb06880434c0/fvets-07-572425-g0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/45f0fa529979/fvets-07-572425-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/909fe3d03203/fvets-07-572425-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/c03c2431750b/fvets-07-572425-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/87bc28c74a3a/fvets-07-572425-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5edb/7725767/bb06880434c0/fvets-07-572425-g0005.jpg

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