Baek Seung-Hwa, Park Jung-Eun
College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
Animals (Basel). 2025 Jan 9;15(2):149. doi: 10.3390/ani15020149.
SADS-CoV, a recently identified bat coronavirus HKU2-associated swine coronavirus, is a malignant pathogen that causes acute diarrhea, severe diarrhea, and weight loss in infected piglets. The virus was first detected in Guangdong Province, China, in 2017 and has since been observed in Jiangxi, Fujian, and Guangxi Provinces. In 2023, the virus was detected in Henan Province, in inland China. This virus can infect various cell lines, including human cell lines, showing significant potential for cross-species transmission and posing a possible zoonotic threat. However, the molecular biology of SADS-CoV remains largely unknown, and there are no commercially available therapeutics or vaccines to prevent SADS-CoV infection. In this review, an update on progress in SADS-CoV research is provided, with a focus on the history of outbreaks, the characteristics of the virus, its interactions with the host, and developments in therapeutics and vaccines.
SADS-CoV是一种最近发现的与蝙蝠冠状病毒HKU2相关的猪冠状病毒，是一种恶性病原体，可导致受感染仔猪出现急性腹泻、严重腹泻和体重减轻。该病毒于2017年首次在中国广东省被检测到，此后在江西、福建和广西三省也有发现。2023年，在中国内陆的河南省检测到该病毒。这种病毒可以感染包括人类细胞系在内的各种细胞系，显示出显著的跨物种传播潜力，并构成可能的人畜共患病威胁。然而，SADS-CoV的分子生物学在很大程度上仍然未知，并且没有可用于预防SADS-CoV感染的商业治疗方法或疫苗。在这篇综述中，提供了SADS-CoV研究进展的最新情况，重点关注疫情爆发的历史、病毒的特征、其与宿主的相互作用以及治疗方法和疫苗的进展。
