Rowlands D J
Wellcome Foundation Ltd., Kent, United Kingdom.
Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 2):S31-5. doi: 10.1164/ajrccm/152.4_Pt_2.S31.
Recent developments in our understanding of the molecular structure and functioning of the human rhinoviruses are briefly reviewed. The determination of virus structure at near atomic resolution has provided a wealth of information that can be used to help interpret dynamic properties of the virus. The mechanisms involved in capsid assembly, attachment to cell surfaces, uncoating, and the initiation of infection and antibody-mediated neutralization of infectivity can all be examined afresh in the light of the structural data. In addition, molecular techniques for manipulating and analyzing the biological properties of nucleic acids and proteins are providing a wealth of information on details of the replication machinery of the viruses. Probably one of the least understood aspects of viral replication is the precise nature of the interactions between host and viral components during infection. Unfortunately, despite all of these impressive scientific advances the cure for the common cold is still elusive.
本文简要回顾了我们对人类鼻病毒分子结构和功能理解的最新进展。接近原子分辨率的病毒结构测定提供了大量信息，可用于帮助解释病毒的动态特性。根据结构数据，可以重新审视衣壳组装、细胞表面附着、脱壳、感染起始以及抗体介导的感染性中和等过程中涉及的机制。此外，用于操纵和分析核酸及蛋白质生物学特性的分子技术，也为病毒复制机制的细节提供了大量信息。病毒复制中最不为人理解的方面之一，可能是感染过程中宿主与病毒成分之间相互作用的确切性质。不幸的是，尽管取得了所有这些令人瞩目的科学进展，普通感冒的治愈方法仍然难以捉摸。
