Sham P C, Zerbin-Rüdin E, Kendler K S
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Psychiatr Genet. 1995 Summer;5(2):57-62. doi: 10.1097/00041444-199522000-00002.
Nearly all previous evidence of the familial transmission of age at onset of schizophrenia has been in siblings and twins. In his paper, Bruno Schulz examined the age at onset distribution of schizophrenia in affected parent and offspring pairs, using a systematic series of ascertained cases (n = 106), as well as a second series of chronic in-patients (n = 36). The parent-offspring correlation in age at onset, for cases with a definite diagnosis in the systematically ascertained series, was estimated at 0.346 (95% confidence interval 0.134, 0.528). Schulz did not test for differences between the two series and between males and females, but our reanalysis, using correlational methods and a mixed linear model, did not detect any significant differences. These results are consistent with previous findings that age at onset of schizophrenia is influenced by familial factors which may be genetic.
几乎所有先前关于精神分裂症发病年龄家族传递的证据都来自兄弟姐妹和双胞胎。在他的论文中，布鲁诺·舒尔茨使用一系列系统确定的病例（n = 106）以及另一组慢性住院患者（n = 36），研究了患病父母与子女对中精神分裂症的发病年龄分布。在系统确定的系列中确诊的病例，发病年龄的亲子相关性估计为0.346（95%置信区间0.134，0.528）。舒尔茨没有检验这两组病例之间以及男性和女性之间的差异，但我们使用相关方法和混合线性模型进行的重新分析未发现任何显著差异。这些结果与先前的研究结果一致，即精神分裂症的发病年龄受可能是遗传的家族因素影响。
