Hungerford J L
Department of Ophthalmology, Saint Bartholomew's Hospital, London, UK.
Br Med Bull. 1995 Jul;51(3):694-716. doi: 10.1093/oxfordjournals.bmb.a072987.
Most melanomas in the orbital region are primary tumours. The uveal tract is the commonest site though the skin of the eyelids, the conjunctiva and, very occasionally, the orbit itself may be involved. Direct spread may cause the tumour to present in an adjacent structure so that a uveal tract melanoma with an extrascleral nodule may appear to arise in the conjunctiva or in the orbit whilst a conjunctival melanoma may first be apparent in the adjacent eyelid skin. Metastatic deposits from cutaneous melanoma may occasionally present in the eye or ocular adnexa.
眼眶区域的大多数黑色素瘤是原发性肿瘤。葡萄膜是最常见的发病部位，不过眼睑皮肤、结膜，以及极少见的眼眶本身也可能受累。直接蔓延可导致肿瘤出现在相邻结构中，因此伴有巩膜外结节的葡萄膜黑色素瘤可能看似起源于结膜或眼眶，而结膜黑色素瘤可能首先在相邻的眼睑皮肤中显现。皮肤黑色素瘤的转移灶偶尔也可能出现在眼内或眼附属器。
