Weiss R R, Macri J N, Balsam D
Obstet Gynecol. 1978 Mar;51(3):299-305. doi: 10.1097/00006250-197803000-00009.
Amniography for the visualization and confirmation of suspected neural tube defect was performed in 9 midtrimester gravidas. In all cases, amniotic fluid alpha-feto protein (AFP) was abnormally elevated. Four cases of anencephaly and one of spina bifida were demonstrated by amniography. These pregnancies were terminated and the defects were confirmed by gross pathologic examination. In 4 remaining cases, amniography was normal. Three of these pregnancies proceeded to term, culminating in the birth of a normal child. The fourth patient had spontaneous abortion of a normal fetus at 23 weeks of gestation. The experience reported here suggests that amniography is an important adjunctive diagnostic technique in the prenatal diagnosis of neural tube defect, and if used correctly, may significantly reduce the chance of false-positive diagnosis.
对9例孕中期孕妇进行了羊膜造影，以可视化和确认疑似神经管缺陷。所有病例中，羊水甲胎蛋白（AFP）均异常升高。羊膜造影显示4例无脑儿和1例脊柱裂。这些妊娠均终止，缺陷经大体病理检查证实。其余4例羊膜造影正常。其中3例妊娠至足月，最终产下正常婴儿。第四例患者在妊娠23周时自然流产了一个正常胎儿。此处报告的经验表明，羊膜造影是神经管缺陷产前诊断中的一项重要辅助诊断技术，若使用得当，可显著降低假阳性诊断的几率。
