Barasch A, Gofa A, Krutchkoff D J, Eisenberg E
Department of Oral Diagnosis, University of Connecticut Health Center, Farmington, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Aug;80(2):183-7. doi: 10.1016/s1079-2104(05)80200-8.
Recent studies suggest that patients with carcinoma of the gingiva exhibit demographic features that differ from those of persons with squamous carcinoma at other intraoral sites. In this study, we sought to explore this hypothesis in greater detail. Records from the University of Connecticut Oral Biopsy Service from 1975 through 1992 inclusive were surveyed for cases of oral carcinoma. A total of 577 cases were retrieved and analyzed with respect to prevalence, gender distribution, and age at diagnosis. We found that the gingiva (alveolar ridge included) was the third most common site for oral squamous carcinoma after carcinoma of the floor of the mouth and tongue. Further, the relative proportion of gingival cancer versus carcinoma at other intraoral subsites remained essentially constant throughout the study period. Male-to-female ratios were significantly greater for cancer of the floor of the mouth as compared with both cancer of the tongue and cancer of the gingiva (ridge included). Age was not a significant predictor of oral cancer subsite, and there were no apparent differences between carcinoma of the dentate gingiva and that of the edentulous ridge. Results of this study indicate that gender-specific predilections exist for squamous cell carcinoma at different intraoral subsites. These differences suggest the possibility of different etiologic factors and pathogenetic mechanisms involved in carcinoma of the gingiva compared with surface carcinoma at other intraoral sites.
最近的研究表明，牙龈癌患者呈现出与口腔其他部位鳞状细胞癌患者不同的人口统计学特征。在本研究中，我们试图更详细地探究这一假设。对康涅狄格大学口腔活检服务中心1975年至1992年（含）的记录进行了口腔癌病例调查。共检索到577例病例，并对其患病率、性别分布和诊断时的年龄进行了分析。我们发现，牙龈（包括牙槽嵴）是仅次于口底癌和舌癌的第三大口腔鳞状细胞癌常见部位。此外，在整个研究期间，牙龈癌与口腔其他亚部位癌症的相对比例基本保持不变。与舌癌和牙龈癌（包括牙槽嵴）相比，口底癌的男女比例显著更高。年龄不是口腔癌亚部位的显著预测因素，有牙牙龈癌和无牙牙槽嵴癌之间没有明显差异。本研究结果表明，不同口腔亚部位的鳞状细胞癌存在性别特异性偏好。这些差异表明，与口腔其他部位的表面癌相比，牙龈癌可能涉及不同的病因和发病机制。
