Barasch A, Morse D E, Krutchkoff D J, Eisenberg E
Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030-1605.
Cancer. 1994 Feb 1;73(3):509-13. doi: 10.1002/1097-0142(19940201)73:3<509::aid-cncr2820730303>3.0.co;2-x.
Studies assessing risk factors for oral cancer do not generally report results for specific oral sites. The purpose of the current study was to examine differences in the distribution of age, gender, and tobacco use by intraoral site in a series of oral cancer cases.
Information on gender, age at diagnosis, and lesion location was obtained for all incident cases of oral squamous cell carcinoma diagnosed through the University of Connecticut Oral Pathology Biopsy Service during the period 1987-1991 (N = 150). Information on tobacco use was obtained through a telephone interview or from medical or dental records.
The tongue, floor of the mouth (FOM), and gingiva, respectively, were the most commonly affected sites. The male-to-female ratio was greatest for FOM cancer (3.4) and lowest for gingival cancer (0.5). The mean age at diagnosis did not differ significantly by site. The percentage of smokers among cases of FOM, tongue, and gingival cancer was 97%, 64%, and 50%, respectively. When multiple logistic regression was used to compare FOM and gingival cancer, gender and smoking remained significant predictors. The odds of smoking among patients with FOM cancer were 32 times the odds of smoking among patients with gingival cancer (odds ratio for age, gender adjusted = 32.6, 3.3-323.5).
The findings suggest that cancer of the FOM is more strongly associated with smoking than is cancer of the gingiva and, perhaps, the tongue. The reported results should be interpreted cautiously in light of study limitations, which include the absence of information on alcohol consumption and lack of a noncancer control group.
评估口腔癌风险因素的研究通常不会报告特定口腔部位的结果。本研究的目的是在一系列口腔癌病例中，研究口腔内不同部位在年龄、性别和烟草使用分布上的差异。
获取了1987 - 1991年期间通过康涅狄格大学口腔病理活检服务诊断出的所有口腔鳞状细胞癌新发病例的性别、诊断时年龄和病变位置信息（N = 150）。通过电话访谈或医疗或牙科记录获取烟草使用信息。
舌、口底（FOM）和牙龈分别是最常受累的部位。口底癌的男女比例最高（3.4），牙龈癌的男女比例最低（0.5）。各部位诊断时的平均年龄无显著差异。口底癌、舌癌和牙龈癌病例中的吸烟者比例分别为97%、64%和50%。当使用多因素逻辑回归比较口底癌和牙龈癌时，性别和吸烟仍然是显著的预测因素。口底癌患者吸烟的几率是牙龈癌患者吸烟几率的32倍（年龄、性别调整后的优势比 = 32.6，3.3 - 323.5）。
研究结果表明，口底癌比牙龈癌以及可能比舌癌与吸烟的关联更强。鉴于研究存在局限性，包括缺乏饮酒信息和没有非癌症对照组，应谨慎解读所报告的结果。
