Pelletier D L, Frongillo E A, Schroeder D G, Habicht J P
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.
Bull World Health Organ. 1995;73(4):443-8.
Conventional methods of classifying causes of death suggest that about 70% of the deaths of children (aged 0-4 years) worldwide are due to diarrhoeal illness, acute respiratory infection, malaria, and immunizable diseases. The role of malnutrition in child mortality is not revealed by these conventional methods, despite the long-standing recognition of the synergism between malnutrition and infectious diseases. This paper describes a recently-developed epidemiological method to estimate the percentage of child deaths (aged 6-59 months) which could be attributed to the potentiating effects of malnutrition in infectious disease. The results from 53 developing countries with nationally representative data on child weight-for-age indicate that 56% of child deaths were attributable to malnutrition's potentiating effects, and 83% of these were attributable to mild-to-moderate as opposed to severe malnutrition. For individual countries, malnutrition's total potentiating effects on mortality ranged from 13% to 66%, with at least three-quarters of this arising from mild-to-moderate malnutrition in each case. These results show that malnutrition has a far more powerful impact on child mortality than is generally appreciated, and suggest that strategies involving only the screening and treatment of the severely malnourished will do little to address this impact. The methodology provided in this paper makes it possible to estimate the effects of malnutrition on child mortality in any population for which prevalence data exist.
传统的死因分类方法表明,全球范围内约70%的儿童(0至4岁)死亡是由腹泻病、急性呼吸道感染、疟疾和可免疫疾病导致的。尽管长期以来人们都认识到营养不良与传染病之间存在协同作用,但这些传统方法并未揭示营养不良在儿童死亡率中的作用。本文介绍了一种最近开发的流行病学方法,用于估计儿童(6至59个月)死亡中可归因于营养不良对传染病的增强作用的百分比。来自53个发展中国家的具有全国代表性的儿童年龄别体重数据结果表明,56%的儿童死亡可归因于营养不良的增强作用,其中83%归因于轻度至中度而非重度营养不良。对于各个国家而言,营养不良对死亡率的总体增强作用范围为13%至66%,每种情况下至少四分之三是由轻度至中度营养不良引起的。这些结果表明,营养不良对儿童死亡率的影响比普遍认为的要大得多,这表明仅涉及筛查和治疗重度营养不良儿童的策略对解决这一影响作用不大。本文提供的方法使得能够估计营养不良对任何有患病率数据的人群中儿童死亡率的影响。