Murata-Kamiya N, Kamiya H, Iwamoto N, Kasai H
Department of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Carcinogenesis. 1995 Sep;16(9):2251-3. doi: 10.1093/carcin/16.9.2251.
Oxygen free radicals cause extensive chemical changes in DNA, including base and sugar modifications and strand breaks. In the present study we found that a mutagen, glyoxal, is produced by exposure of DNA to an oxygen radical forming system (5 mM FeSO4-EDTA, 37 degrees C, 60 min). It was produced with 17 times higher efficiency than 8-hydroxydeoxyguanosine. Thus it is possible that the formation of glyoxal is one of the major types of damage in DNA exposed to oxygen free radicals.
