Fasce L, Vianello M G, Tolentino P
Boll Ist Sieroter Milan. 1978 Nov 30;57(5):654-66.
Chromosome aberrations of short and long-term cultured lymphocytes have been studied in 12 subjects with chronic hepatitis B. Short-term cultures show "stickiness", aneuploidy, and fragmentations. Long-term cultures show minor damages, made up almost totally of "lacunae" and sporadic fragmentations. Major size chromosomes appear to be more affected, among the latter those containing sites for the interferon. This latter findings would suggest that the interferon decrease in patients might be bound, even only partially to the virus-linked chromosome alterations.
对12例慢性乙型肝炎患者短期和长期培养的淋巴细胞的染色体畸变进行了研究。短期培养显示出“粘连”、非整倍体和断裂。长期培养显示出轻微损伤，几乎完全由“空白区”和散在的断裂组成。较大的染色体似乎受影响更大，其中包含干扰素位点的染色体受影响更明显。后一发现表明，患者体内干扰素水平的降低可能与病毒相关的染色体改变有关，即使只是部分相关。
