Ambrosio G, De Marco R, Loffredo L, Magli A
Istituto di Oftalmologia, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli, Italy.
Doc Ophthalmol. 1995;89(3):211-8. doi: 10.1007/BF01203374.
Seventeen patients with biopsy-confirmed mitochondrial progressive external ophthalmoplegia underwent electroretinography and visual evoked potential testing to checkerboard-reversal stimuli to investigate subclinical visual dysfunction. Seven patients (41%) had impaired Snellen visual acuity that was never less than 0.6. Thirteen patients (76%) showed electroretinographic and/or visual evoked potential alterations, whereas six (35%) showed impairment on both tests. Two patients showed delayed VEP P100 latency without fundus, electroretinographic or visual acuity anomalies. Visual dysfunctions were not related to age at onset and course of the disease.
17例经活检确诊为线粒体进行性眼外肌麻痹的患者接受了视网膜电图和对棋盘格反转刺激的视觉诱发电位测试，以研究亚临床视觉功能障碍。7例患者（41%）的斯内伦视力受损，但从未低于0.6。13例患者（76%）表现出视网膜电图和/或视觉诱发电位改变，而6例（35%）在两项测试中均表现受损。2例患者VEP P100潜伏期延迟，眼底、视网膜电图或视力无异常。视觉功能障碍与发病年龄和病程无关。
