Cornish J W, Maany I, Fudala P J, Neal S, Poole S A, Volpicelli P, O'Brien C P
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA.
Drug Alcohol Depend. 1995 Jun;38(3):221-7. doi: 10.1016/0376-8716(95)01102-5.
We report on a double-blind, placebo-controlled study of carbamazepine (CBZ) treatment for cocaine dependence. A previously reported uncontrolled study found CBZ to be a beneficial pharmacotherapy for cocaine dependence. Statistical analyses were performed on data from 82 subjects who were randomized to 10 weeks' treatment with either CBZ, titrated to 4-12 micrograms/ml, (n = 37) or placebo (n = 45). The two treatment groups did not differ for primary outcome measures of retention time in treatment, urine samples positive for cocaine metabolite, subject reported desire for cocaine or for subject reported side-effects. CBZ was not an effective treatment in this study.
我们报告了一项关于卡马西平（CBZ）治疗可卡因依赖的双盲、安慰剂对照研究。之前一项未经控制的研究发现CBZ是治疗可卡因依赖的一种有效药物疗法。对82名受试者的数据进行了统计分析，这些受试者被随机分为两组，一组接受CBZ治疗10周，剂量滴定至4 - 12微克/毫升（n = 37），另一组接受安慰剂治疗（n = 45）。在治疗保留时间、可卡因代谢物检测呈阳性的尿液样本、受试者报告的对可卡因的渴望或受试者报告的副作用等主要结局指标方面，两个治疗组没有差异。在本研究中，CBZ不是一种有效的治疗方法。
