Benigni R, Andreoli C, Giuliani A
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Rome, Italy.
Environ Mol Mutagen. 1995;26(2):155-62. doi: 10.1002/em.2850260209.
In previous investigations, we studied the relationships between the profiles of the qualitative responses of in vitro short-term tests (mutation in Salmonella typhimurium, chromosomal aberrations in CHO cells, sister chromatid exchanges in CHO cells, and mutation in mouse lymphoma cells) and common sets of chemicals. In this paper, we address the study of the quantitative responses (potency). We show that two analyses point to similar patterns of relationships: the mutation in mouse lymphoma cells assay is most similar to the CHO sister chromatid exchange assay, and the Salmonella assay is most similar to the CHO chromosomal aberrations assay.
在先前的研究中，我们研究了体外短期试验（鼠伤寒沙门氏菌中的突变、中国仓鼠卵巢细胞中的染色体畸变、中国仓鼠卵巢细胞中的姐妹染色单体交换以及小鼠淋巴瘤细胞中的突变）的定性反应概况与常见化学物质组之间的关系。在本文中，我们探讨定量反应（效力）的研究。我们表明，两种分析指向相似的关系模式：小鼠淋巴瘤细胞试验中的突变与中国仓鼠卵巢细胞姐妹染色单体交换试验最为相似，而沙门氏菌试验与中国仓鼠卵巢细胞染色体畸变试验最为相似。
