Leung H W, Ballantyne B
Union Carbide Corporation, Danbury, CT 06817-0001, USA.
Mutat Res. 1997 Sep 18;393(1-2):7-15. doi: 10.1016/s1383-5718(97)00104-6.
Three alkylalkanolamines, N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine, were evaluated for potential genotoxic activity using the Salmonella/microsome reverse gene mutation test, the CHO/HGPRT forward gene mutation test, a sister chromatid exchange test in cultured CHO cells, and an in vivo peripheral blood micronucleus test in Swiss-Webster mice. None of the three alkylalkanolamines produced any significant or dose-related increases in the frequencies of mutations, sister chromatid exchanges or micronuclei. These results indicate that N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine are not genotoxic in the tests conducted.
使用沙门氏菌/微粒体反向基因突变试验、CHO/HGPRT正向基因突变试验、培养的CHO细胞姐妹染色单体交换试验以及瑞士韦伯斯特小鼠体内外周血微核试验，对三种烷基烷醇胺（N,N-二甲基乙醇胺、N-甲基二乙醇胺和叔丁基二乙醇胺）的潜在遗传毒性活性进行了评估。这三种烷基烷醇胺均未使突变、姐妹染色单体交换或微核的频率出现任何显著增加或与剂量相关的增加。这些结果表明，在所进行的试验中，N,N-二甲基乙醇胺、N-甲基二乙醇胺和叔丁基二乙醇胺没有遗传毒性。
