Shen C Y, Hsu K, Wang D, Yan H C
Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Experientia. 1995 Sep 29;51(9-10):956-60. doi: 10.1007/BF01921747.
Pentoxifylline (PTX), a methylxanthine derivative, effectively prevents acute lung injury in different animal models. To investigate whether PTX would attenuate acute lung injury induced by microemboli resulting from treatment with calcium chloride (CaCl2) suspension, an isolated blood-perfused rat lung model was used. Pretreatment with PTX prevented the increase in pulmonary arterial pressure (PAP), lung weight gain and protein concentration in the lavage fluid after CaCl2 treatment.
己酮可可碱（PTX）是一种甲基黄嘌呤衍生物，能有效预防不同动物模型中的急性肺损伤。为研究PTX是否能减轻氯化钙（CaCl2）悬液治疗所致微栓子引起的急性肺损伤，采用了离体血液灌注大鼠肺模型。PTX预处理可预防CaCl2治疗后肺动脉压（PAP）升高、肺重量增加和灌洗液中蛋白质浓度升高。
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