Perez F M, Rose J C, Schwartz J
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA.
Mol Cell Endocrinol. 1995 Jun;111(2):C1-6. doi: 10.1016/0303-7207(95)03575-r.
We review in this article recent findings on the effects of cell proximity (nearness to each other) on anterior pituitary cell function in vitro. Important cellular processes, including protein synthesis, basal hormone release, response to hypothalamic regulatory factors and signal transduction can change as a function of the distance between adjacent cells. These findings, together with a growing body of evidence on intrapituitary intercellular interactions, form a basis for proposing a model of anterior pituitary cell regulation. In this scheme extrapituitary, intracellular and intercellular signaling pathways all contribute and interact to control secretory processes in cells.
在本文中，我们综述了近期关于细胞 proximity（彼此靠近）对体外垂体前叶细胞功能影响的研究结果。重要的细胞过程，包括蛋白质合成、基础激素释放、对下丘脑调节因子的反应以及信号转导，都可能随相邻细胞间距离的变化而改变。这些发现，连同越来越多关于垂体内部细胞间相互作用的证据，为提出垂体前叶细胞调节模型奠定了基础。在这个模型中，垂体外、细胞内和细胞间的信号通路都相互作用，共同控制细胞的分泌过程。
