达哌唑与毛果芸香碱的相加缩瞳作用。
The additive miotic effects of dapiprazole and pilocarpine.
作者信息
Geyer O, Loewenstein A, Shalmon B, Neudorfer M, Lazar M
机构信息
Department of Ophthalmology, Sourasky Medical Center, Tel-Aviv, Israel.
出版信息
Graefes Arch Clin Exp Ophthalmol. 1995 Jul;233(7):448-51. doi: 10.1007/BF00180951.
BACKGROUND
Since dapiprazole on alpha-adrenergic agent, produces miosis by paralyzing the dilator muscle, and pilocarpine, a parasympathetic drug, causes miosis by affecting the sphincter, we speculated that the two drugs might have additive effects.
METHODS
The additive miotic actions of pilocarpine 2% and dapiprazole 0.5% were evaluated by comparing the effects of two drugs given together and alone on the reversal of mydriasis induced by tropicamide (0.5%) and phenylephrine (10%) in one eye each of 60 healthy volunteers.
RESULTS
Dapiprazole and pilocarpine together induced miosis significantly faster than each drug alone, showing additive effects.
CONCLUSION
Co-administration of dapiprazole and pilocarpine at the end of the eye examination will induce fast pupillary constriction, which might be useful in preventing the development of an acute attack of angle-closure glaucoma in patients with anatomically narrow angles.
背景
由于达哌唑这种α-肾上腺素能药物通过麻痹散瞳肌产生缩瞳作用，而毛果芸香碱这种副交感神经药物通过影响瞳孔括约肌引起缩瞳，我们推测这两种药物可能具有相加作用。
方法
通过比较60名健康志愿者每只眼睛单独使用和联合使用2%毛果芸香碱和0.5%达哌唑对由0.5%托吡卡胺和10%去氧肾上腺素引起的散瞳的逆转作用，评估其相加缩瞳作用。
结果
达哌唑和毛果芸香碱联合使用引起缩瞳的速度明显快于每种药物单独使用，显示出相加作用。
结论
在眼科检查结束时联合使用达哌唑和毛果芸香碱将诱导快速瞳孔收缩，这可能有助于预防房角狭窄患者急性闭角型青光眼发作。
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