Umesaki N, Fukumasu H, Miyama M, Kawabata M, Ogita S
Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
Gynecol Obstet Invest. 1995;40(1):5-7. doi: 10.1159/000292291.
We measured the plasma granulocyte colony stimulating factor (G-CSF) concentrations in pregnant women to evaluate the association between G-CSF and increased neutrophil counts that has been observed during pregnancy. We examined 96 pregnant and 10 nonpregnant women. The G-CSF concentrations were assayed using a sandwich enzyme immunoassay. The G-CSF concentrations in pregnant women were significantly higher at all times than those of nonpregnant women. The G-CSF concentrations were also significantly higher during than before labor. The plasma G-CSF concentrations were positively correlated with the neutrophil counts during the 3rd trimester only. In conclusion, increased G-CSF concentrations may be related to the increases in neutrophil counts in pregnant women, especially during the 3rd trimester.
我们测量了孕妇血浆粒细胞集落刺激因子（G-CSF）的浓度，以评估G-CSF与孕期观察到的中性粒细胞计数增加之间的关联。我们检查了96名孕妇和10名非孕妇。使用夹心酶免疫测定法测定G-CSF浓度。孕妇的G-CSF浓度在所有时间均显著高于非孕妇。分娩期间的G-CSF浓度也显著高于分娩前。仅在孕晚期，血浆G-CSF浓度与中性粒细胞计数呈正相关。总之，G-CSF浓度升高可能与孕妇中性粒细胞计数增加有关，尤其是在孕晚期。
