Nagano N, Yoshimoto H, Nishitoba T, Sato H, Miyata S, Kusaka M, Jing S B, Yamaguchi T
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Nihon Yakurigaku Zasshi. 1995 Aug;106(2):123-33. doi: 10.1254/fpj.106.123.
The effects of chitosan-coated dialdehyde cellulose (Chitosan DAC), a newly developed oral adsorbent of urea and ammonia, were examined in rats with progressive chronic renal failure (CRF) induced by adriamycin. CRF rats induced by repeated injections of adriamycin were fed a diet containing chitosan DAC (5% content) or Kremezin (5% content), an oral charcoal adsorbent (AST-120) under strict paired-feeding for four months. CRF rats that received both a normal diet and Kremezin showed progressive azotemia, hyperphosphatemia, hyperlipidemia, proteinuria, and anemia, and began to die from 9 weeks after feeding started. In contrast, chitosan DAC-treatment showed marked prolongation of the survival period and decreases in blood urea nitrogen, serum creatinine, and serum phosphate. In addition, chitosan DAC-treatment ameliorated anemia in CRF rats, although hyperlipidemia and proteinuria were not improved. Furthermore, fecal weight, fecal water content, fecal nitrogen and fecal sodium were markedly increased, and the apparent protein ratio was decreased in CRF rats fed a diet containing chitosan DAC for 9 weeks. In contrast, none of these effects were observed in CRF rats receiving Kremezin. These observations suggest the further possibility of using oral adsorbent therapy for CRF patients.
对一种新开发的尿素和氨口服吸附剂——壳聚糖包被的二醛纤维素（壳聚糖二醛纤维素），在阿霉素诱导的进行性慢性肾衰竭（CRF）大鼠中进行了效果研究。对通过反复注射阿霉素诱导的CRF大鼠，在严格配对喂养条件下，喂食含壳聚糖二醛纤维素（含量5%）或克雷莫辛（含量5%，一种口服活性炭吸附剂（AST - 120））的饲料，持续四个月。接受正常饮食和克雷莫辛的CRF大鼠出现进行性氮质血症、高磷血症、高脂血症、蛋白尿和贫血，从开始喂食9周后开始死亡。相比之下，壳聚糖二醛纤维素治疗显著延长了生存期，并降低了血尿素氮、血清肌酐和血清磷酸盐水平。此外，壳聚糖二醛纤维素治疗改善了CRF大鼠的贫血，尽管高脂血症和蛋白尿未得到改善。此外，喂食含壳聚糖二醛纤维素饲料9周的CRF大鼠，粪便重量、粪便含水量、粪便氮和粪便钠显著增加，表观蛋白比率降低。相比之下，接受克雷莫辛的CRF大鼠未观察到这些效应。这些观察结果提示了对CRF患者使用口服吸附剂疗法的进一步可能性。
