遗传因素在支气管癌中的作用。基于一对同卵双胞胎中的间变性肺癌病例。

Role of genetic factors in bronchial cancer. Based upon a case of anaplastic lung carcinoma in identical twins.

作者信息

Nores J M, Dalayeun J F, Chebat J, Dieudonne P, Remy J M

机构信息

Department of Internal Medicine, University of Paris, Hôpital Raymond Poincaré, Garches, France.

出版信息

Hum Genet. 1995 Oct;96(4):483-4. doi: 10.1007/BF00191812.

DOI:10.1007/BF00191812

PMID:7557976

Abstract

Having observed homozygotic identical twin brothers suffering simultaneously from anaplastic bronchial cancer leading rapidly to death in both cases, the authors assessed the frequency of such cases. The available literature failed to reveal any identical observations, although four cases of twins suffering from bronchial cancer featuring different histologies (three epidermoidal and one bronchiolar-alveolar) were noted. Statistics show that, in the area where the observed twins were living, anaplastic cancer occurs each year in 0.39% of 53-year-old men. The case of these twins therefore supports the idea of the role of genetic factors in the determination of bronchial cancer.

摘要

在观察到同卵双胞胎兄弟同时患上间变性支气管癌且两人均迅速死亡后，作者评估了此类病例的发生频率。现有文献未能揭示任何相同的观察结果，不过记录了4例患支气管癌的双胞胎病例，其组织学特征各不相同（3例为表皮样癌，1例为细支气管肺泡癌）。统计数据表明，在观察到的这对双胞胎居住的地区，53岁男性中间变性癌的年发病率为0.39%。因此，这对双胞胎的病例支持了遗传因素在支气管癌发病中起作用的观点。