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卡介苗（Bcg）基因座对巨噬细胞对双态真菌白色念珠菌反应的影响。

Influence of the Bcg locus on macrophage response to the dimorphic fungus Candida albicans.

作者信息

Puliti M, Radzioch D, Mazzolla R, Barluzzi R, Bistoni F, Blasi E

机构信息

Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.

出版信息

Infect Immun. 1995 Oct;63(10):4170-3. doi: 10.1128/iai.63.10.4170-4173.1995.

DOI:10.1128/iai.63.10.4170-4173.1995
PMID:7558336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173587/
Abstract

The Bcg/Ity/Lsh gene (candidate Nramp) controls natural resistance to several parasites, such as Mycobacterium bovis, Leishmania donovani, and Salmonella typhimurium. Using two macrophage (M phi) cell lines (B10R and B10S) derived from mouse strains congenic at Bcg, we found that M phi s from resistant mice (B10R M phi s) act more effectively against the two morphogenetic forms of the dimorphic fungus Candida albicans compared with M phi s from susceptible mice (B10S M phi s). Moreover, when assessed for tumor necrosis factor secretion in response to the hyphal form of C. albicans, B10R M phi s are significantly more effective at expressing this secretory function than are B10S M phi s, closely resembling the trend of response to lipopolysaccharide. Overall, these results provide insight into the influence of the Bcg locus on the M phi response to C. albicans.

摘要

卡介苗/伊顿因子/利什曼原虫抗性基因（候选天然抗性相关巨噬细胞蛋白基因）控制对多种寄生虫的天然抗性，如牛分枝杆菌、杜氏利什曼原虫和鼠伤寒沙门氏菌。利用从在卡介苗基因座上基因纯合的小鼠品系衍生而来的两种巨噬细胞系（B10R和B10S），我们发现，与易感小鼠的巨噬细胞（B10S巨噬细胞）相比，抗性小鼠的巨噬细胞（B10R巨噬细胞）对双态真菌白色念珠菌的两种形态发生形式具有更有效的作用。此外，当评估对白色念珠菌菌丝体形式的反应中肿瘤坏死因子的分泌时，B10R巨噬细胞在表达这种分泌功能方面比B10S巨噬细胞显著更有效，这与对脂多糖的反应趋势非常相似。总体而言，这些结果为卡介苗基因座对巨噬细胞对白色念珠菌反应的影响提供了见解。

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