1型腺病毒与卡他莫拉菌（布兰汉菌）不会协同作用诱发栗鼠中耳炎。
Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchilla.
作者信息
Bakaletz L O, Murwin D M, Billy J M
机构信息
Department of Otolaryngology, College of Medicine, Ohio State University, Columbus 43210.
出版信息
Infect Immun. 1995 Oct;63(10):4188-90. doi: 10.1128/iai.63.10.4188-4190.1995.
Abstract
A chinchilla model of otitis media in which adenovirus compromise of the tubotympanum facilitates the subsequent induction of middle ear disease was used to investigate Moraxella (Branhamella) catarrhalis pathogenesis. Intranasally inoculated M. catarrhalis did readily colonize the nasopharynx of this host; however, despite evidence of viral infection and tubotympanal compromise, M. catarrhalis did not induce culture-positive otitis media in this model.
摘要
利用一种中耳炎的栗鼠模型来研究卡他莫拉菌（以前称卡他布兰汉菌）的发病机制，在该模型中，腺病毒对咽鼓管鼓室的损害促进了随后中耳疾病的诱发。经鼻接种的卡他莫拉菌确实很容易在该宿主的鼻咽部定植；然而，尽管有病毒感染和咽鼓管鼓室损害的证据，但在该模型中卡他莫拉菌并未诱发培养阳性的中耳炎。
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