• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1型腺病毒与卡他莫拉菌（布兰汉菌）不会协同作用诱发栗鼠中耳炎。

Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchilla.

作者信息

Bakaletz L O, Murwin D M, Billy J M

机构信息

Department of Otolaryngology, College of Medicine, Ohio State University, Columbus 43210.

出版信息

Infect Immun. 1995 Oct;63(10):4188-90. doi: 10.1128/iai.63.10.4188-4190.1995.

DOI:10.1128/iai.63.10.4188-4190.1995
PMID:7558341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173592/
Abstract

A chinchilla model of otitis media in which adenovirus compromise of the tubotympanum facilitates the subsequent induction of middle ear disease was used to investigate Moraxella (Branhamella) catarrhalis pathogenesis. Intranasally inoculated M. catarrhalis did readily colonize the nasopharynx of this host; however, despite evidence of viral infection and tubotympanal compromise, M. catarrhalis did not induce culture-positive otitis media in this model.

摘要

利用一种中耳炎的栗鼠模型来研究卡他莫拉菌（以前称卡他布兰汉菌）的发病机制，在该模型中，腺病毒对咽鼓管鼓室的损害促进了随后中耳疾病的诱发。经鼻接种的卡他莫拉菌确实很容易在该宿主的鼻咽部定植；然而，尽管有病毒感染和咽鼓管鼓室损害的证据，但在该模型中卡他莫拉菌并未诱发培养阳性的中耳炎。

相似文献

1
Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchilla.1型腺病毒与卡他莫拉菌（布兰汉菌）不会协同作用诱发栗鼠中耳炎。
Infect Immun. 1995 Oct;63(10):4188-90. doi: 10.1128/iai.63.10.4188-4190.1995.
2
Moraxella (Branhamella) catarrhalis-induced experimental otitis media in the chinchilla.卡他莫拉菌（布兰汉菌属）诱发的栗鼠实验性中耳炎
Acta Otolaryngol. 1994 Jul;114(4):415-22. doi: 10.3109/00016489409126080.
3
Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2.利用 Chinchilla 模型评估卡他莫拉菌丝状血凝素样蛋白 MhaB1 和 MhaB2 的疫苗潜力。
PLoS One. 2013 Jul 2;8(7):e67881. doi: 10.1371/journal.pone.0067881. Print 2013.
4
Ribotyping of strains of Moraxella (Branhamella) catarrhalis cultured from the nasopharynx and middle ear of children with otitis media.对从患有中耳炎的儿童鼻咽部和中耳培养出的卡他莫拉菌（布兰汉菌）菌株进行核糖体分型。
Acta Otolaryngol. 1998 Jun;118(3):381-5. doi: 10.1080/00016489850183476.
5
Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.呼吸道合胞病毒促进卡他莫拉菌引起的上行性实验性中耳炎。
PLoS One. 2012;7(6):e40088. doi: 10.1371/journal.pone.0040088. Epub 2012 Jun 29.
6
Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis.利用青紫蓝兔模型研究卡他莫拉菌鼻咽部定植时的基因表达。
Infect Immun. 2012 Mar;80(3):982-95. doi: 10.1128/IAI.05918-11. Epub 2011 Dec 19.
7
Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling.流感嗜血杆菌和卡他莫拉菌在多微生物中耳炎中的间接致病性是通过种间群体感应信号传递的。
mBio. 2010 Jul 6;1(3):e00102-10. doi: 10.1128/mBio.00102-10.
8
The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.莫拉氏菌属 DNA 甲基转移酶 ModM3 是一种表遗传调控因子，影响中耳炎动物模型中细菌的存活。
BMC Microbiol. 2019 Dec 9;19(1):276. doi: 10.1186/s12866-019-1660-y.
9
Experimental otitis media with Moraxella (Branhamella) catarrhalis.
Ann Otol Rhinol Laryngol. 1996 Mar;105(3):234-41. doi: 10.1177/000348949610500311.
10
Epidemiology of Moraxella catarrhalis in children during the first 2 years of life: relationship to otitis media.1至2岁儿童卡他莫拉菌的流行病学：与中耳炎的关系。
J Infect Dis. 1994 Jun;169(6):1312-7. doi: 10.1093/infdis/169.6.1312.

引用本文的文献

1
Innate Immunity in the Middle Ear Mucosa.中耳黏膜的固有免疫。
Front Cell Infect Microbiol. 2021 Oct 29;11:764772. doi: 10.3389/fcimb.2021.764772. eCollection 2021.
2
Replication of type 5 adenovirus promotes middle ear infection by Streptococcus pneumoniae in the chinchilla model of otitis media.在栗鼠中耳炎模型中，5型腺病毒的复制会促进肺炎链球菌引发的中耳感染。
Pathog Dis. 2015 Mar;73(2):1-8. doi: 10.1111/2049-632X.12216. Epub 2015 Feb 26.
3
Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model.鉴定一种外膜脂蛋白，该脂蛋白参与了在动物模型中卡他莫拉菌的鼻咽定植。
Infect Immun. 2014 Jun;82(6):2287-99. doi: 10.1128/IAI.01745-14. Epub 2014 Mar 18.
4
Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2.利用 Chinchilla 模型评估卡他莫拉菌丝状血凝素样蛋白 MhaB1 和 MhaB2 的疫苗潜力。
PLoS One. 2013 Jul 2;8(7):e67881. doi: 10.1371/journal.pone.0067881. Print 2013.
5
Development of a LacZ-based transcriptional reporter system for use with Moraxella catarrhalis.基于 LacZ 的转录报告系统的开发，用于卡他莫拉菌。
Plasmid. 2013 Mar;69(2):180-5. doi: 10.1016/j.plasmid.2012.11.003. Epub 2012 Dec 4.
6
Nasopharyngeal bacterial interactions in children.儿童鼻咽部细菌相互作用。
Emerg Infect Dis. 2012 Nov;18(11):1738-45. doi: 10.3201/eid1811.111904.
7
Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.呼吸道合胞病毒促进卡他莫拉菌引起的上行性实验性中耳炎。
PLoS One. 2012;7(6):e40088. doi: 10.1371/journal.pone.0040088. Epub 2012 Jun 29.
8
Bacterium-generated nitric oxide hijacks host tumor necrosis factor alpha signaling and modulates the host cell cycle in vitro.细菌产生的一氧化氮在体外劫持宿主肿瘤坏死因子α信号并调节宿主细胞周期。
J Bacteriol. 2012 Aug;194(15):4059-68. doi: 10.1128/JB.00476-12. Epub 2012 May 25.
9
Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis.利用青紫蓝兔模型研究卡他莫拉菌鼻咽部定植时的基因表达。
Infect Immun. 2012 Mar;80(3):982-95. doi: 10.1128/IAI.05918-11. Epub 2011 Dec 19.
10
High detection rates of nucleic acids of a wide range of respiratory viruses in the nasopharynx and the middle ear of children with a history of recurrent acute otitis media.在有反复发作急性中耳炎病史的儿童的鼻咽部和中耳中，广泛的呼吸道病毒的核酸检测率很高。
J Med Virol. 2011 Nov;83(11):2008-17. doi: 10.1002/jmv.22221.

本文引用的文献

1
Modeling adenovirus type 1-induced otitis media in the chinchilla: effect on ciliary activity and fluid transport function of eustachian tube mucosal epithelium.
J Infect Dis. 1993 Oct;168(4):865-72. doi: 10.1093/infdis/168.4.865.
2
Epidemiology of Moraxella catarrhalis in children during the first 2 years of life: relationship to otitis media.1至2岁儿童卡他莫拉菌的流行病学：与中耳炎的关系。
J Infect Dis. 1994 Jun;169(6):1312-7. doi: 10.1093/infdis/169.6.1312.
3
Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.1型腺病毒与不可分型流感嗜血杆菌在实验性中耳炎栗鼠模型中的协同作用
Infect Immun. 1994 May;62(5):1710-8. doi: 10.1128/iai.62.5.1710-1718.1994.
4
Purification and characterization of a high-molecular-weight outer membrane protein of Moraxella (Branhamella) catarrhalis.卡他莫拉菌（布兰汉菌属）一种高分子量外膜蛋白的纯化与特性分析
Infect Immun. 1994 Apr;62(4):1150-5. doi: 10.1128/iai.62.4.1150-1155.1994.
5
Genotypic and phenotypic relatedness of 80 strains of Branhamella catarrhalis of worldwide origin.
FEMS Microbiol Lett. 1994 Jun 1;119(1-2):155-9. doi: 10.1111/j.1574-6968.1994.tb06882.x.
6
Immune response to Moraxella catarrhalis in children with otitis media: opsonophagocytosis with antigen-coated latex beads.中耳炎患儿对卡他莫拉菌的免疫反应：用抗原包被的乳胶珠进行调理吞噬作用。
Ann Otol Rhinol Laryngol. 1994 Jul;103(7):522-4. doi: 10.1177/000348949410300704.
7
Moraxella (Branhamella) catarrhalis-induced experimental otitis media in the chinchilla.卡他莫拉菌（布兰汉菌属）诱发的栗鼠实验性中耳炎
Acta Otolaryngol. 1994 Jul;114(4):415-22. doi: 10.3109/00016489409126080.
8
The major heat-modifiable outer membrane protein CD is highly conserved among strains of Branhamella catarrhalis.
Mol Microbiol. 1993 Oct;10(1):87-97. doi: 10.1111/j.1365-2958.1993.tb00906.x.
9
Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.不可分型流感嗜血杆菌表达的菌毛在中耳炎发病机制及预防中的作用以及菌毛蛋白亚基与外膜蛋白A的相关性
Infect Immun. 1994 May;62(5):2002-20. doi: 10.1128/iai.62.5.2002-2020.1994.
10
Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infants.鼻咽部细菌定植可预测澳大利亚原住民婴儿中耳炎的极早期发病和持续情况。
Pediatr Infect Dis J. 1994 Nov;13(11):983-9. doi: 10.1097/00006454-199411000-00009.