Nieman D C, Cook V D, Henson D A, Suttles J, Rejeski W J, Ribisl P M, Fagoaga O R, Nehlsen-Cannarella S L
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, USA.
Int J Sports Med. 1995 Jul;16(5):334-7. doi: 10.1055/s-2007-973015.
Sixteen female breast cancer patients who had been diagnosed (3.0 +/- 1.2 years previous to the study) and undergone surgery, chemotherapy, and/or radiation treatment were randomly assigned to exercise and nonexercise groups. Pre- and post-study measurements were taken for aerobic performance, leg strength, and concentrations of circulating lymphocyte subsets and natural killer cell cytotoxic activity (NKCA). Exercise training consisted of 60 minutes of supervised weight training and aerobic activity three times each week for eight weeks. Although subjects in the exercise groups demonstrated some modest improvement in the various aerobic and strength tests, NKCA and concentrations of circulating T and NK cells were not significantly altered relative to the nonexercise group. This study suggests that moderate exercise over an eight-week period has no significant effect on the function of in vitro natural killer cells in breast cancer patients.
16名已确诊的女性乳腺癌患者（在研究前3.0±1.2年）接受了手术、化疗和/或放疗，被随机分为运动组和非运动组。在研究前后测量了有氧能力、腿部力量、循环淋巴细胞亚群浓度和自然杀伤细胞细胞毒性活性（NKCA）。运动训练包括每周三次、每次60分钟的有监督的重量训练和有氧运动，持续八周。尽管运动组的受试者在各种有氧和力量测试中表现出一定程度的改善，但与非运动组相比，NKCA以及循环T细胞和NK细胞的浓度没有显著变化。这项研究表明，八周的适度运动对乳腺癌患者体外自然杀伤细胞的功能没有显著影响。
