Nieman D C, Brendle D, Henson D A, Suttles J, Cook V D, Warren B J, Butterworth D E, Fagoaga O R, Nehlsen-Cannarella S L
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA.
Int J Sports Med. 1995 Jul;16(5):329-33. doi: 10.1055/s-2007-973014.
The purpose of this study was to compare natural killer cell cytotoxic activity (NKCA) and Con A-induced lymphocyte proliferation (T cell function) in athletes versus nonathletes, with measurement of natural killer (NK) and T cells to allow a comparison on a "per-cell" adjusted basis. Eighteen young male endurance athletes (10 runners and 8 cyclists) with a mean VO2max of 70.7 +/- 1.3 ml.kg-1.min-1 and 6.6 +/- 0.8 years of competitive experience were compared with 11 nonathletic male adults (47.6 +/- 3.1 ml.kg-1.min-1). Concentrations of circulating leukocyte and lymphocyte subsets, including NK and T cells, were not significantly different between groups. NKCA and T cell function also did not differ between groups, whether expressed unadjusted or adjusted on a per-cell basis. For all subjects combined, both NKCA and T cell function were unrelated to VO2max (r = 0.005, p = 0.98; r = 0.007, p = 0.97, respectively). These data do not support the contention that immune function, as measured in this study, is altered in endurance athletes.
本研究的目的是比较运动员与非运动员的自然杀伤细胞细胞毒性活性（NKCA）和刀豆蛋白A诱导的淋巴细胞增殖（T细胞功能），并测量自然杀伤（NK）细胞和T细胞，以便在“每细胞”调整的基础上进行比较。将18名年轻男性耐力运动员（10名跑步运动员和8名自行车运动员）与11名非运动男性成年人进行比较，这些运动员的平均最大摄氧量为70.7±1.3 ml.kg-1.min-1，有6.6±0.8年的比赛经验，而非运动男性成年人的平均最大摄氧量为47.6±3.1 ml.kg-1.min-1。两组之间循环白细胞和淋巴细胞亚群（包括NK细胞和T细胞）的浓度没有显著差异。NKCA和T细胞功能在两组之间也没有差异，无论是未调整还是以每细胞为基础进行调整后。对于所有受试者而言，NKCA和T细胞功能均与最大摄氧量无关（r分别为0.005，p = 0.98；r = 0.007，p = 0.97）。这些数据不支持以下观点：在本研究中所测量的免疫功能在耐力运动员中会发生改变。
