Ohtani S, Matsushima Y, Ohhira H, Watanabe A
Department of Forensic Medicine, Kanagawa Dental College, Japan.
Growth Dev Aging. 1995 Spring-Summer;59(1-2):55-61.
In addition to L-aspartic acid, D-aspartic acid was detected in the protein (collagen) of rat teeth. The content of D-aspartic acid in rat molars increased significantly with age, showing a close correlation with age (r = 0.965-0.993), whereas in rat incisors D-aspartic acid did not increase. This suggests that there is little metabolic activity in rat molars after their formation. The amount of D-aspartic acid present in molars of a single rat was in the order first molars > second molars > third molars. This indicates that the amount of D-aspartic acid is higher in teeth formed earlier, corresponding to the time of their formation. The rate of racemization in rat molars was about ten-fold higher than that in human dentin, suggesting the importance of body temperature in the rate of racemization. These findings also suggest that D-aspartic acid is present in the teeth of other animals.
除L-天冬氨酸外，在大鼠牙齿的蛋白质（胶原蛋白）中还检测到了D-天冬氨酸。大鼠臼齿中D-天冬氨酸的含量随年龄显著增加，与年龄呈密切相关性（r = 0.965 - 0.993），而在大鼠门牙中D-天冬氨酸并未增加。这表明大鼠臼齿形成后代谢活性很低。单只大鼠臼齿中D-天冬氨酸的含量顺序为第一臼齿>第二臼齿>第三臼齿。这表明在较早形成的牙齿中D-天冬氨酸含量较高，这与它们的形成时间相对应。大鼠臼齿中的消旋化速率比人牙本质中的约高十倍，表明体温对消旋化速率的重要性。这些发现还表明其他动物的牙齿中也存在D-天冬氨酸。
