Ohta Y
Department of Veterinary Science, Faculty of Agriculture, Tottori University, Japan.
Int Rev Cytol. 1995;160:1-52. doi: 10.1016/s0074-7696(08)61552-1.
In female rats, administration of androgen during early postnatal life results in anovulatory sterility characterized by polyfollicular ovaries and persistent vaginal cornification in adulthood. In these androgen-sterilized rats, the acyclic male pattern of gonadotropin secretion results from permanent damage to hypothalamic centers normally responsive to steroid feedback. The capacity of the endometrium to differentiate into deciduoma in response to endometrial stimulation is markedly reduced in the uterus of the androgenized rats receiving an appropriate regimen of progesterone and estrogen injections. The hypothesis is presented that the lowered uterine responsiveness in the androgenized rats is largely ascribable to the effect of androgen given neonatally rather than to the influence of continued exposure to ovarian estrogen. This review deals with the nature of the uterine response to ovarian hormones and the deciduogenic stimulus in androgenized rats in order to verify the mechanism involved in androgen action on the neonatal uterus.
在雌性大鼠出生后早期给予雄激素，会导致成年期无排卵性不育，其特征为多囊卵巢和持续的阴道角化。在这些雄激素绝育的大鼠中，促性腺激素分泌的无周期性雄性模式是由于下丘脑中心受到永久性损伤，而这些中心通常对类固醇反馈有反应。在接受适当孕酮和雌激素注射方案的雄激素化大鼠子宫中，子宫内膜对子宫内膜刺激分化为蜕膜瘤的能力明显降低。有人提出假说，雄激素化大鼠子宫反应性降低在很大程度上归因于新生期给予雄激素的影响，而非持续暴露于卵巢雌激素的影响。本综述探讨了雄激素化大鼠子宫对卵巢激素的反应性质以及蜕膜形成刺激，以验证雄激素对新生子宫作用的机制。
