Takewaki K, Ohta Y
Endocrinol Jpn. 1975 Feb;22(1):79-82. doi: 10.1507/endocrj1954.22.79.
When rats ovariectomized at 3 days of age and given a single injection of 1.25 mg testosterone propionate on the next day became 60 days old, they were given 3 daily injections of 0.2 mug estradiol-17 beta followed by 7 daily combined injections of 2 mg progesterone and 0.2 mug estradiol. Incidence of deciduomata in reaction to uterine trauma applied on the 4th day of the progesterone-estradiol injections was almost as high as that in neonatally ovariectomized, non-androgenized rats, but the response was significantly smaller in size in androgenized rats than in non-androgenized animals. If females similarly operated on were given injections of 0.1 mug estradiol for 30 days prior to 7 daily injections of progesterone-estradiol, deciduoma formation in androgenized rats was markedly reduced in both incidence and size of the response. In non-androgenized group, deciduoma formation was not significantly affected by chronic administration of estradiol.Accordingly, it is likely that, although androgen injected during neonatal life is responsible for the reduction of uterine responsiveness in androgen-sterilized rats (Takewaki and Ohta, 1974) continued exposure of the uterus to estrogen may play a co-operative role in the event.
3日龄时接受卵巢切除术的大鼠，次日注射1.25毫克丙酸睾酮，60日龄时，每日注射3次0.2微克雌二醇-17β，随后每日联合注射7次2毫克孕酮和0.2微克雌二醇。在孕酮-雌二醇注射第4天施加子宫创伤后，蜕膜瘤的发生率几乎与新生期卵巢切除、未雄激素化的大鼠相同，但雄激素化大鼠的反应在大小上明显小于未雄激素化的动物。如果对同样接受手术的雌性大鼠在每日注射7次孕酮-雌二醇之前30天注射0.1微克雌二醇，雄激素化大鼠的蜕膜瘤形成在发生率和反应大小上均明显减少。在未雄激素化组中，长期给予雌二醇对蜕膜瘤形成无显著影响。因此，虽然新生期注射雄激素导致雄激素绝育大鼠子宫反应性降低（武胁和太田，1974年），但子宫持续暴露于雌激素可能在这一过程中起协同作用。
