Austin J R, Kershiznek M M, McGill D, Austin S G
Department of Head and Neck Surgery, University of Texas, M. D. Anderson Cancer Center, Houston, USA.
Head Neck. 1995 Mar-Apr;17(2):161-5. doi: 10.1002/hed.2880170217.
Breast cancer affects 150,000 women a year in the United States. Breast carcinoma that is metastatic to the paranasal sinus (PNS) is rare. A patient with breast cancer treated recently at the University of Texas M. D. Anderson Cancer Center developed bilateral metastasis to the ethmoid sinuses. This case prompted a review of the incidence of this disease, its treatment, and outcome.
A review of the published reports dating back to 1939 of breast carcinoma that was metastatic to the PNS was performed. In addition, autopsy series in the breast oncology literature were reviewed for cases of breast carcinoma that was metastatic to the PNS.
From this review, we identified only eight cases of breast carcinoma that was metastatic to the PNS. All cases were unilateral and presented as mass lesions. Despite treatment, all patients died soon after diagnosis.
We conclude that breast carcinoma metastatic to the PNS is rare and has been uniformly fatal because, as disseminated disease, it does not respond well to conventional systemic therapies.
在美国，每年有15万名女性受乳腺癌影响。转移性至鼻窦（PNS）的乳腺癌很罕见。德克萨斯大学MD安德森癌症中心近期治疗的一名乳腺癌患者出现双侧筛窦转移。该病例促使对这种疾病的发病率、治疗方法及结果进行回顾。
对自1939年以来已发表的关于转移性至PNS的乳腺癌报告进行回顾。此外，还查阅了乳腺肿瘤学文献中的尸检系列，以查找转移性至PNS的乳腺癌病例。
通过此次回顾，我们仅发现8例转移性至PNS的乳腺癌病例。所有病例均为单侧，表现为肿块病变。尽管进行了治疗，但所有患者在诊断后不久均死亡。
我们得出结论，转移性至PNS的乳腺癌很罕见，且一直是致命性的，因为作为播散性疾病，它对传统全身治疗反应不佳。
